Xiao-Bing Wang, Xing-Ran Jiang, Xi-Ying Yu, Lin Wang, Shun He, Fei-Yue Feng, Li-Ping Guo, Wei Jiang and Shih-Hsin Lu Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody-based therapy Cancer Science 105
Serum MIC1 may serve as a diagnostic marker and an independent prognostic factor for ESCC. Additionally,monitoring of serum MIC1 after surgery is useful in evaluation of early recurrence. Notably, this study highlights that the over-expression of MIC1 was associated with lymph node metastasis and MIC1 can act as a therapeutic target for antibody-based therapy in the treatment of ESCC.
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