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Tao Ren, Yi Qing, Nan Dai, Mengxia Li, Chengyuan Qian, Yuxin Yang, Yi Cheng, Zheng Li, Shiheng Zhang, Zhaoyang Zhong and Dong Wang Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells Cancer Science 105

Version of Record online: 27 JAN 2014 | DOI: 10.1111/cas.12334

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APE1-siRNA markedly inhibited tumor angiogenesis by down-regulating FGF2/FGFR3 in vitro and in vivo. Therefore, the APE1-FGF2/FGFR3 pathway identified in this study may be a valuable molecular target for osteosarcoma therapy.

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