Tian-Quan Yang, Xiao-Jun Lu, Ting-Feng Wu, Da-Dong Ding, Zhao-Hui Zhao, Gui-Lin Chen, Xue-Shun Xie, Bin Li, Yong-Xin Wei, Ling-Chuan Guo, Yu Zhang, Yu-Lun Huang, You-Xin Zhou and Zi-Wei Du MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway Cancer Science 105
Version of Record online: 11 FEB 2014 | DOI: 10.1111/cas.12351
We first report that miR-16 and NF-κB1expression were inversely correlated to glioma levels in the same patient samples. We further identified the miR-16 as a negative regulator of tumor growth and invasion, both in vitro and in vivo. Mechanistically the tumor-suppressive role of miR-16 can be attributed to inhibition of BCL-2 and NF-kappaB1/MMP9 signaling pathways.
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