Li Sun, Lili Liu, Xiangqiang Liu, Yafang Wang, Mengbin Li, Liping Yao, Jianjun Yang, Genlin Ji, Changcun Guo, Yanglin Pan, Shuhui Liang, Biaoluo Wang, Jie Ding, Hongwei Zhang and Yongquan Shi MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer Cancer Science 105
Article first published online: 12 MAY 2014 | DOI: 10.1111/cas.12414
In this study, our experimental results showed that gastric cancer MDR cell lines mediated CAM-DR via up-regulation of Bcl-2 by MGr1-Ag interaction with LN. Further study found that, as a receptor of ECM components, MGr1-Ag/37LRP may activate the downstream signal pathway PI3K/AKT and MAPK/ERK via the interaction with pFAK.
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