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Xiangjiao Meng, Renben Wang, Zhaoqin Huang, Jianbo Zhang, Rui Feng, Xiaoqing Xu, Kunli Zhu, Xue Dou, Dong Chen and Jinming Yu Human epidermal growth factor receptor-2 expression in locally advanced rectal cancer: Association with response to neoadjuvant therapy and prognosis Cancer Science 105

Version of Record online: 16 MAY 2014 | DOI: 10.1111/cas.12421

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HER-2 status was determined in pretreatment biopsies by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). HER-2 positivity before nCRT were significantly associated with poor 5-year disease-free survival (P = 0.015) and 5-year overall survival (P = 0.026). HER-2 status can not predict tumor response to nCRT in LARC, but it provides us with a trend that HER-2 positive tumor may be resistant to nCRT.

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