Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, Archana Dilip, Alfonso Quintás-Cardama, Timothy J. McDonnell, Sattva S. Neelapu, Larry W. Kwak, Sharon Shacham, Michael Kauffman, Yoko Tabe, Masako Yokoo, Shinya Kimura, Michael Andreeff and Kensuke Kojima Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma Cancer Science 105
Article first published online: 3 JUN 2014 | DOI: 10.1111/cas.12430
The selective XPO1 inhibitor KPT-185 potently activates p53-mediated transcription toward apoptosis in MCL. XPO1 inhibitors may provide a novel therapeutic tool for the therapy of MCL that often has suppressed p53 and high levels of XPO1.
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