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Manish Jain, William R. Surin, Ankita Misra, Prem Prakash, Vishal Singh, Vivek Khanna, Satish Kumar, Hefazat H. Siddiqui, Kanwal Raj, Manoj K. Barthwal and Madhu Dikshit Antithrombotic Activity of a Newly Synthesized Coumarin Derivative 3-(5-Hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide Chemical Biology & Drug Design 81

Version of Record online: 28 MAR 2013 | DOI: 10.1111/cbdd.12000

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Coumarin derivatives [C3] demonstrated antithrombotic efficacy without any adverse effect on bleeding time. Mode of antithrombotic action of C3 seems to be due to anti-platelet activity and to a certain extent by anti-coagulant mechanisms. Relationship among effects on clotting times, anti-thrombotic efficacy, and bleeding risk with C3 must be established in clinical trials.

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