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Palmiro Poltronieri, Pietro I. D’Urso, Valeria Mezzolla and Oscar F. D’Urso Potential of Anti-Cancer Therapy Based on Anti-miR-155 Oligonucleotides in Glioma and Brain Tumours Chemical Biology & Drug Design 81

Version of Record online: 17 DEC 2012 | DOI: 10.1111/cbdd.12002

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The decrease in viability of primary cultures of glioblastoma multiforme (GBM) in response to GABA stimulation, evaluated with MTT [3-(4.5-dimethylthiazol-2-yl)-2.5-diphenol tetrazolium bromide] assays. Glioblastoma multiforme cells transfected with a 2′-O-methyl-oligonucleotide complementary to miR-155 (2′OMe-miR-155) and an irrelevant 2′-O-methyloligonucleotide (2′OMe-EGFP) were grown for 48 h. The induction of GABRA1 mRNA expression after transfection with the anti-miR-155 antisense was monitored by means of Northern blot assays, and confirmed that GABA receptors are re-expressed when miR-155 is depleted in GBM cells.

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