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Megumi Shimoyama, Peter W. Schiller, Naohito Shimoyama, Satoshi Toyama and Hazel H. Szeto Superior Analgesic Effect of H-Dmt-D-Arg-Phe-Lys-NH2 ([Dmt1]DALDA), a Multifunctional Opioid Peptide, Compared to Morphine in a Rat Model of Neuropathic Pain Chemical Biology & Drug Design 80

Version of Record online: 3 SEP 2012 | DOI: 10.1111/cbdd.12003

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The effect of [Dmt1]DALDA, a synthetic multifunctional opioid peptide, was compared with morphine in a model of experimental neuropathic pain. Systemic [Dmt1]DALDA was more effective than morphine in increasing thermal pain threshold in thermal hyperalgesia due to neuropathic pain produced by spinal nerve ligation in rats.

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