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Taner Keskin, Belgin S. Isgor, Yasemin G. Isgor and Funda Yukruk Evaluation of Perylenediimide Derivatives for Potential Therapeutic Benefits on Cancer Chemotherapy Chemical Biology & Drug Design 80

Version of Record online: 31 AUG 2012 | DOI: 10.1111/cbdd.12004

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The analysis of novel N,N′-disubstituted perylenediimides with amino acid functional groups and their 1,7-dibromo derivatives revealed their GST and PTK inhibitory activity at nanomolar to micromolar range. The inhibition profiles were investigated through their effects on central signaling component Src, and on cytosolic GSTs from liver homogenates. As the GSTs are highly overexpressed in cancer cells, their inhibition by perylenediimides might offer new clues on their mechanism of action and open interesting perspectives for future tumor therapies.

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