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Sinjan Choudhary and Nand Kishore Unraveling the Energetics and Mode of the Recognition of Antibiotics Tetracycline and Rolitetracycline by Bovine Serum Albumin Chemical Biology & Drug Design 80

Version of Record online: 31 AUG 2012 | DOI: 10.1111/cbdd.12009

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Tetracycline and rolitetracycline bind to BSA in a sequential manner via a mix of hydrophobic, ionic and hydrogen bonding interactions. The calorimetry in combination with spectroscopy suggest the binding of these drugs at site-2 on BSA. Quantitative and qualitative aspects of the binding interactions and stabilization of the protein in presence of drugs have been discussed


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