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Wataru Aoki, Nao Kitahara, Natsuko Miura, Hironobu Morisaka, Kouichi Kuroda and Mitsuyoshi Ueda Design of a Novel Antimicrobial Peptide Activated by Virulent Proteases Chemical Biology & Drug Design 80

Article first published online: 10 SEP 2012 | DOI: 10.1111/cbdd.12012

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Antimicrobial peptides (AMPs) are promising antibiotics, but administration of an antibiotic with a very broad spectrum of activity increases the risks of other fatal infections. To solve the problem, we designed a novel AMP that is activated by virulent proteases of pathogenic organisms. A designed peptide like the one may protect normal microflora, resulting in enhanced safety as a therapeutic.

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