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Xiaofeng Wang, Aiqun Zhang, Weizheng Ren, Caiyu Chen and Jiahong Dong Genome-wide Inference of Transcription Factor–DNA Binding Specificity in Cell Regeneration Using a Combination Strategy Chemical Biology & Drug Design 80

Article first published online: 10 SEP 2012 | DOI: 10.1111/cbdd.12013

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A combination strategy is used to predict the binding affinity and infer the binding specificity of transcription factor–DNA interactions at the genomic level. It is revealed that the interactives and conformational effects contribute significantly to the sequence-specific recognition.

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