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Jessica P. Anand, Lauren C. Purington, Irina D. Pogozheva, John R. Traynor and Henry I. Mosberg Modulation of Opioid Receptor Ligand Affinity and Efficacy Using Active and Inactive State Receptor Models Chemical Biology & Drug Design 80

Article first published online: 12 SEP 2012 | DOI: 10.1111/cbdd.12014

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Mixed efficacy opioid peptides displaying mu agonist/delta antagonist properties were developed using opioid receptor models of active and inactive states to guide design. This bifunctional pharmacological profile holds great promise for pain treatment with limited tolerance development.

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