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Andrew G. Jamieson, Nicolas Boutard, David Sabatino and William D. Lubell Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery Chemical Biology & Drug Design 81

Article first published online: 17 DEC 2012 | DOI: 10.1111/cbdd.12042

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This critical commentary reviews peptide scanning techniques, which employ natural and non-proteinogneic amino acids to facilitate understanding of structural requirements for peptide biological activity. The value of sequence analysis by such methods is highlighted by examples, in which the elements for peptide affinity and activity have been elucidated and employed to prepare peptidomimetic leads for drug development.

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