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Birgit Koch, Mirko Buchholz, Michael Wermann, Ulrich Heiser, Stephan Schilling and Hans-Ulrich Demuth Probing Secondary Glutaminyl Cyclase (QC) Inhibitor Interactions Applying an in silico-Modeling/Site-Directed Mutagenesis Approach: Implications for Drug Development Chemical Biology & Drug Design 80

Version of Record online: 11 OCT 2012 | DOI: 10.1111/cbdd.12046

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The different binding modes of a potent Glutaminyl Cyclase (QC) inhibitor were analyzed for two different QC’s by in silico methods as well as by mutagenesis investigations. Thereby it is shown that for the human enzyme differences might exists between the binding modes in the crystal structure and the solution state.

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