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Monika Sharma, Sowmya Garigipati, Binita Kundu, Deekshith Vanamala, Arvind Semwal, Dharmarajan Sriram and Perumal Yogeeswari Discovery of Novel 1,2,4-Triazol-5-Ones as Tumor Necrosis Factor-Alpha Inhibitors for the Treatment of Neuropathic Pain Chemical Biology & Drug Design 80

Version of Record online: 9 OCT 2012 | DOI: 10.1111/cbdd.12049

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In the present work, synthetic integration of substituted semicarbazides and various aliphatic, aryl and heteroaryl acids into 1,2,4-triazol-5-ones was accomplished. The compounds suppressed the inflammatory component of the neuropathic pain inhibiting TNF-α and preventing oxidative and nitrosative stress.

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