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Sergio Giannattasio, Nicoletta Guaragnella, Arnaldo A. Arbini and Loredana Moro Stress-Related Mitochondrial Components and Mitochondrial Genome as Targets of Anticancer Therapy Chemical Biology & Drug Design 81

Version of Record online: 17 DEC 2012 | DOI: 10.1111/cbdd.12057

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Alterations in mitochondrial structure and functions have long been observed in cancer cells, thus targeting mitochondria as an anti-cancer therapeutic strategy has gained momentum recently. We will review the achievements and perspectives in the elucidation of the molecular basis for developing mitochondrial-targeted compounds as potential anti-cancer agents with special attention to mitochondrial DNA mutations and mitochondrial dysfunction.

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