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Ya-Tuan Ma, Hua-Fang Fan, Yu-Qi Gao, He Li, An-Ling Zhang and Jin-Ming Gao Natural Products as Sources of New Fungicides (I): Synthesis and Antifungal Activity of Acetophenone Derivatives Against Phytopathogenic Fungi Chemical Biology & Drug Design 81

Article first published online: 28 MAR 2013 | DOI: 10.1111/cbdd.12064

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A series of acetophenone derivatives have been synthesized and tested for their antifungal activities. Of them 12 derivatives exhibited more potent antifungal effects on some phytopathogens than a positive control hymexazol. Especially, compound 3b (IC50 = 10–19 μg/mL) was found to be the most active and might be a potential lead structure. The SAR of these acetophenones is also discussed.

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