Doseok Hwang, Hye-Jin Park, Eun-Kyung Seo, Joo Y. Oh, Sang Y. Ji, Dong K. Park and Yoongho Lim Effects of Flavone Derivatives on Antigen-Stimulated Degranulation in RBL-2H3 Cells Chemical Biology & Drug Design 81
The activation level of mast cells is reflected in their degree of degranulation. This can in turn be determined by measuring the amount of β-hexosaminidase release, a key parameter in degranulation. In this study, 40 flavone derivatives were evaluated for their inhibition of degranulation in RBL-2H3 cells. 3′,7-Dihydroxyflavone inhibited degranulation (IC50 = 13.56 μM), which was comparable to PP2 used as a control. We report quantitative relationships between the structural properties of flavones and their inhibitory effects on degranulation.
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