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Vani Munusamy, Beow Keat Yap, Michael J. C. Buckle, Stephen W. Doughty and Lip Yong Chung Structure-Based Identification of Aporphines with Selective 5-HT2A Receptor-Binding Activity Chemical Biology & Drug Design 81

Version of Record online: 14 NOV 2012 | DOI: 10.1111/cbdd.12069

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A series of aporphines was investigated using a combination of in silico and in vitro screening approaches and (R)-roemerine and (±)-nuciferine were found to have selective 5-HT2A receptor binding affinity (Ki = 62 nM annd 139 nM, respectively).

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