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Silvia C. Lopes, Carla Ribeiro and Paula Gameiro A New Approach to Counteract Bacteria Resistance: A Comparative Study Between Moxifloxacin and a New Moxifloxacin Derivative in Different Model Systems of Bacterial Membrane Chemical Biology & Drug Design 81

Version of Record online: 27 NOV 2012 | DOI: 10.1111/cbdd.12071

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Distinct factors govern the interaction of moxifloxacin and its metalloantibiotic with model systems of bacterial membranes, which clearly points out for a different translocation route. The metalloantibiotic is more sensitive to different model systems of bacterial membranes composition and shows no partition to model systems of mammalian cells. Cardiolipin’s absence from model systems of bacterial membranes bias conclusions that can be taken from lipid-drug interactions.

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