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Hong-Yan Lin, Wei Chen, Jing Shi, Wen-Yao Kong, Jin-Liang Qi, Xiao-Ming Wang and Yong-Hua Yang Design, Synthesis and Biological Evaluation of Cinnamic Acyl Shikonin Derivatives Chemical Biology & Drug Design 81

Article first published online: 26 NOV 2012 | DOI: 10.1111/cbdd.12077

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A series of cinnamic acyl shi-konin derivatives have been synthesized and their biological activities were also evaluated as potential anti-cancer agents. Among them, 8b showed the most potent anti- proliferate activity of SW872-s, A875 and A549 cell lines. Furthermore, the western blotting result showed 8b induced the apoptosis of A875 cell line by up-regulating the quantity of cleaved caspase-3, 7, 9 and cleaved PARP.

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