Irene Ruberto, Balazs Szoor, Rachel Clark and Keith R. Matthews Investigating Mammalian Tyrosine Phosphatase Inhibitors as Potential ‘Piggyback’ Leads to Target Trypanosoma brucei Transmission Chemical Biology & Drug Design 81
Trypanosomes are parasites of sub-Saharan Africa responsible for important human and animal disease. TbPTP1 is a tyrosine phosphatase that acts as a master regulator of trypanosome life cycle development that when inhibited causes a premature developmental response that is lethal to the parasite. We demonstrate that inhibitors targeting mammalian PTP1B can also inhibit TbPTP1, providing a potential piggyback strategy to exploit drugs for obesity and diabetes for the treatment for neglected tropical disease.
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