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Laura Raguine, Marina Ali, Veronika Bender, Eve Diefenbach, Munikumar Reddy Doddareddy, David Hibbs and Nicholas Manolios Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure–Function Relationships Chemical Biology & Drug Design 81

Version of Record online: 26 NOV 2012 | DOI: 10.1111/cbdd.12080

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Core Peptide (CP) is an immunosuppressive peptide, the sequence of which is derived from the T-cell antigen receptor alpha chain transmembrane region. Here we report the role each constituent amino acid plays within CP using an alanine scan and the amino acid effect on function using a biological antigen presentation assay. We have now identified that there are four hydrophobic regions and one positively charged region within CP necessary for biological activity.

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