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Rosivaldo S. Borges, Glaécia A. N. Pereira, Joyce K. L. Vale, Luiz C. S. França, Marta C. Monteiro, Cláudio N. Alves and Albérico B. F. da Silva Design and Evaluation of 4-Aminophenol and Salicylate Derivatives as Free-Radical Scavenger Chemical Biology & Drug Design 81

Version of Record online: 13 FEB 2013 | DOI: 10.1111/cbdd.12096

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The drug design and evaluation of the free radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives using DFT methods and the rapid methods of evaluation DPPH and TBARS. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol.

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