E-mail

E-mail a Wiley Online Library Link

Megan Hogan, Medhanit Bahta, Scott Cherry, George T. Lountos, Joseph E. Tropea, Bryan M. Zhao, Terrence R. Burke Jr, David S. Waugh and Robert G. Ulrich Biomolecular Interactions of Small-molecule Inhibitors Affecting the YopH Protein Tyrosine Phosphatase Chemical Biology & Drug Design 81

Article first published online: 13 FEB 2013 | DOI: 10.1111/cbdd.12097

Thumbnail image of graphical abstract

We have developed competitive and direct binding methods to examine small-molecule inhibitors of protein tyrosine phosphatase (PTPase) activity. Focusing on the Yersinia outer protein H (YopH), a potent bacterial PTPase, we describe how an understanding of the kinetic interactions involving YopH, peptide substrates, and small-molecule inhibitors of PTPase activity can be beneficial for inhibitor screening and we further translate these results into a microarray assay for high-throughput screening.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH