Ying Yang, Wei Zhang, Jiagao Cheng, Yun Tang, Yanqing Peng and Zhong Li Pharmacophore, 3D-QSAR, and Bayesian Model Analysis for Ligands Binding at the Benzodiazepine Site of GABAA Receptors: the Key Roles of Amino Group and Hydrophobic Sites Chemical Biology & Drug Design 81
Pharmacophore modeling, 3D-QSAR analysis and Bayesian model studies have been performed on ligands binding at the BZD site. All the results revealed that a hydrogen-bond donor (e.g. N-H) and a hydrophobic group (e.g. Br) are critical structural features for the ligands binding at the BZD site. That could be useful in future ligand design of GABAA receptor.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf