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Yan Wu, Liang-Peng Sun, Long-Xu Ma, Jian Che, Ming-Xia Song, Xun Cui and Hu-Ri Piao Synthesis and Biological Evaluation of [1,2,4]Triazolo[3,4-a]phthalazine and Tetrazolo[5,1-a]phthalazine Derivatives Bearing Substituted Benzylpiperazine Moieties as Positive Inotropic Agents Chemical Biology & Drug Design 81

Version of Record online: 26 MAR 2013 | DOI: 10.1111/cbdd.12101

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Two series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives were synthesized and evaluated for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit-heart preparations.

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