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Anupam Maurya, Gaurav R. Dwivedi, Mahendra P. Darokar and Santosh K. Srivastava Antibacterial and Synergy of Clavine Alkaloid Lysergol and its Derivatives Against Nalidixic Acid-Resistant Escherichia coli Chemical Biology & Drug Design 81

Article first published online: 21 MAR 2013 | DOI: 10.1111/cbdd.12103

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Lysergol (1) and derivatives (214) did not possess antibacterial activity of their own, but in combination, they significantly reduced the minimum inhibitory concentration (MIC) of Nalidixic acid as well as tetracycline. Lysergol and its derivatives 10 and 11 inhibited ATP-dependent efflux pumps, which was evident by ATPase inhibition and down-regulation of multidrug ABC transporter ATP-binding protein (yojI) gene.

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