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Daniel Scott, Jhong-Min Chen, Younsoo Bae and Jürgen Rohr Semi-Synthetic Mithramycin SA Derivatives with Improved AntiCancer Activity Chemical Biology & Drug Design 81

Version of Record online: 4 APR 2013 | DOI: 10.1111/cbdd.12107

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Semi-synthetic modification was used to transform the previously disregarded mithramycin analogue, MTM SA, into a valuable molecule with interesting anti-cancer activity. MTM SA was biologically produced and subsequently synthetically modified with a number of unique side chains, resulting in a new class of mithramycin derivatives.

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