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Sunny Manohar, Shabana I. Khan and Diwan S. Rawat 4-Aminoquinoline-Triazine-Based Hybrids with Improved In Vitro Antimalarial Activity Against CQ-Sensitive and CQ-Resistant Strains of Plasmodium falciparum Chemical Biology & Drug Design 81

Article first published online: 24 APR 2013 | DOI: 10.1111/cbdd.12108

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Systematic chemical modification in the triazine moiety covalently attached via suitable linkers to 4-amino-7-chloroquinolines yielded a series of new 7-chloro-4-aminoquinoline-triazine hybrids exhibiting high in vitro activity against CQ-resistant and CQ-sensitive strains of P. falciparum without any toxicity against mammalian cells.

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