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Elaine S. Coimbra, Luciana M. R. Antinarelli, Adilson D. da Silva, Marcelle L. F. Bispo, Carlos R. Kaiser and Marcus V. N. de Souza 7-Chloro-4-quinolinyl Hydrazones: A Promising and Potent Class of Antileishmanial Compounds Chemical Biology & Drug Design 81

Article first published online: 24 APR 2013 | DOI: 10.1111/cbdd.12112

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In this work, we report the antileishmanial evaluation of twenty 7-chloro-4-quinolinyl hydrazone derivatives (1–20) against promastigotes (four Leishmania species) and amastigotes (L. braziliensis). Compounds 6 and 7 showed a strong leishmanicidal activity against intracellular parasite with IC50 in nanogram levels (30 and 20 ng/mL, respectively), being as active as a reference drug used, amphotericin B.

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