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Mohammad Yusuf, Riaz A. Khan, Maria Khan and Bahar Ahmed An Interactive Human Carbonic Anhydrase-II (hCA-II) Receptor – Pharmacophore Molecular Model & Anti-Convulsant Activity of the Designed and Synthesized 5-Amino-1,3,4-Thiadiazole-2-Thiol Conjugated Imine Derivatives Chemical Biology & Drug Design 81

Article first published online: 24 APR 2013 | DOI: 10.1111/cbdd.12113

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Derived imine compounds, 5-{[1-(4-Chlorophenyl)-3-[4-(methoxy-phenyl)-prop-2-en-1-ylidene] amino}-1,3,4-thiadiazole-2-thiol (2b), 5-{[1-(4-chlorophenyl)-3-[4-(dimethyl amino)phenyl)-prop-2-en-1-ylidene]amino}-1,3,4-thiadiazole-2-thiol (2c) and, 5-{[1-(4-chloro-phenyl)-3-(4-amino-phenyl)-prop-2-en-1-ylidene] amino}-1,3,4-thiadiazole-2-thiol (2f) showed high order (100%) of pharmacological activity in comparison to standard Acetazolamide.

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