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Wenlin Huang, Tao Zuo, Xiao Luo, Hongwei Jin, Zhenming Liu, Zhenjun Yang, Xianghui Yu, Liangren Zhang and Lihe Zhang Indolizine Derivatives as HIV-1 VIF–ElonginC Interaction Inhibitors Chemical Biology & Drug Design 81

Version of Record online: 25 MAY 2013 | DOI: 10.1111/cbdd.12119

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Forty-nine novel 1,3,7-trisubstituted indolizine derivatives were synthesized and evaluated for their activity as HIV-1 VIF-ElonginC interaction inhibitors. Among them, five compounds exhibited obvious anti-HIV-1 activities. Compound 2g showed the most active inhibitor with IC50 of 11.0 μm.

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