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Juliano S. de Toledo, Paulo E. S. Junior, Viviane Manfrim, Camila F. Pinzan, Alexandre S. de Araujo, Angela K. Cruz and Flavio S. Emery Synthesis, Cytotoxicity and In Vitro Antileishmanial Activity of Naphthothiazoles Chemical Biology & Drug Design 81

Version of Record online: 25 MAY 2013 | DOI: 10.1111/cbdd.12123

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The embedment of 2-aminothiazole fragment into naphthoquinoidal structures led to discovery of safe and effective leishmanicidal compounds against promastigote and amastigote stages of Leishmania braziliensis, with very good drug-like properties and probable oral bioavailability.

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