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Gugan Kothandan, Changdev G. Gadhe and Seung J. Cho Theoretical Characterization of Galanin Receptor Type 3 (Gal3) and Its Interaction with Agonist (GALANIN) and Antagonists (SNAP 37889 and SNAP 398299): An In Silico Analysis Chemical Biology & Drug Design 81

Version of Record online: 17 APR 2013 | DOI: 10.1111/cbdd.12128

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Homology modeling of Gal3 receptor and galanin agonist was carried out. Docking of selective antagonists and agonist into the predicted binding site was performed. CoMFA models were obtained using ligand-based and receptor-guided alignment schemes. Crucial residues in the binding site were identified, and mutagenesis studies are warranted.

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