Gugan Kothandan, Changdev G. Gadhe and Seung J. Cho Theoretical Characterization of Galanin Receptor Type 3 (Gal3) and Its Interaction with Agonist (GALANIN) and Antagonists (SNAP 37889 and SNAP 398299): An In Silico Analysis Chemical Biology & Drug Design 81
Homology modeling of Gal3 receptor and galanin agonist was carried out. Docking of selective antagonists and agonist into the predicted binding site was performed. CoMFA models were obtained using ligand-based and receptor-guided alignment schemes. Crucial residues in the binding site were identified, and mutagenesis studies are warranted.
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