Yaqiong Ma, Senbiao Fang, Huanhuan Li, Chao Han, Yan Lu, Yonglong Zhao, Yingqian Liu and Chunyan Zhao Biological Evaluation and Molecular Modelling Study of Podophyllotoxin Derivatives as Potent Inhibitors of Tubulin Polymerization Chemical Biology & Drug Design 82
The anti-proliferative assay against cancer cell lines and tubulin depolymerization experiments proved that podophyllotoxin derivatives can inhibit the polymerization of microtubule and their degradation. The binding modes between the derivatives and tubulin were constructed and hydrophobic interaction was proved to be the governing forces to stabilize the complex. The research helped us to design potent anticancer compounds.
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