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Amaneh Javid, Shahin Ahmadian, Ali A. Saboury, Seyed M. Kalantar and Saeed Rezaei-Zarchi Chitosan-Coated Superparamagnetic Iron Oxide Nanoparticles for Doxorubicin Delivery: Synthesis and Anticancer Effect Against Human Ovarian Cancer Cells Chemical Biology & Drug Design 82

Article first published online: 24 JUL 2013 | DOI: 10.1111/cbdd.12145

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Biodegradable DOX-loaded chitosan-coated SPIO-NPs (69 nm) were prepared, which caused 90% and 87.1% apoptosis in A2780 and OVCAR-3 cells, respectively. Chitosan-coated SPIO-NPs can be used as a better drug delivery system for cancer treatment with lower toxicity as compared to the drug itself.

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