Andrei Leitão, Alexander Schramm and Angelika Eggert Discovery of a New Bioactive Molecule for Neuroblastoma Chemical Biology & Drug Design 82
A novel chemotype of an anti-neuroblastoma molecule was discovered using in silico models and cell-based assays. Our assays showed that this molecule presented a different biological profile from lestaurtinib, mainly because of its resilience for TrkB expressing cells that mimics the aggressive form of the disease in vitro. This compound opens up a new road toward an improved therapeutic possibility for this deadly disease.
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