Qiang Liu, Wen-Jing Yi, Yi-Mei Zhang, Ji Zhang, Liandi Guo and Xiao-Qi Yu Biotinylated Cyclen-Contained Cationic Lipids as Non-Viral Gene Delivery Vectors Chemical Biology & Drug Design 82
Three novel biotinylated cyclen-contained cationic lipids were synthesized. These liposomes showed high cell viability even at high N/P ratios. The tocopherol-modified lipid showed the best transfection efficiency. In addition, higher transfection efficiency was obtained in tumor cells than those obtained in normal cells.
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