E-mail

E-mail a Wiley Online Library Link

Zhichao Zhang, Yan Zhao, Ting Song, Yubo Liu, Xiangqian Li, Pengchen Su and Shenghui Xie Study of Binding Thermodynamics in the Optimization of BH3 Mimetics Chemical Biology & Drug Design 82

Article first published online: 10 SEP 2013 | DOI: 10.1111/cbdd.12161

Thumbnail image of graphical abstract

Isothermal titration calorimetry was used to evaluate the optimization of B-cell lymphoma 2 homology domain 3-mimetics (compounds 16) from a thermodynamic perspective. Owing to 16 overcoming enthalpy-entropy compensation, the affinities of them improved gradually. Comparing 2 with 1, the enthalpy gain indicated the formation of an additional hydrogen bond to myeloid cell leukemia sequence 1 protein.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH