Rinku Baishya, Dipak K. Nayak, Nabanita Chatterjee, Kamal K. Halder, Sanmoy Karmakar and Mita C. Debnath Synthesis, Characterization, and Biological Evaluation of 99mTc(CO)3-Labeled Peptides for Potential Use as Tumor Targeted Radiopharmaceuticals Chemical Biology & Drug Design 83
Three linear peptides were synthesised by changing the amino acid sequence of RGD motif and radiolabeled with freshly prepared [99mTc(CO)3(H2O)3]+ precursor (yield ~ 97%). Radiolabeled peptides were substantially stable up to 24 h when incubated with saline, serum and histidine solution (10−2 m), also exhibited significant and rapid internalization in both EAC and αvβ3-positive B16F10 mouse melanoma cell line. Fast blood clearance, rapid urinary excretion and significantly high tumor to muscle ratios are encouraging enough to carry out further experiments for targeting tumor.
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