E-mail a Wiley Online Library Link

Sandipan Chakraborty, Barnali Mukherjee and Soumalee Basu Pinpointing Proline Substitution to be Responsible for the Loss of Amyloidogenesis in IAPP Chemical Biology & Drug Design 82

Article first published online: 17 JUL 2013 | DOI: 10.1111/cbdd.12172

Thumbnail image of graphical abstract

Molecular dynamics simulation reveals that wild type hIAPP 22-28 fibril fluctuates between different β-sheet topology during the simulation. A25P Substitution is primarily accountable for the loss of amyloidogenecity of the hIAPP peptide. A25P, I26V double mutation also exhibit high fibril destabilization ability. S28P mutation has the least ability to disrupt the amyloid fibril.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.