Sandipan Chakraborty, Barnali Mukherjee and Soumalee Basu Pinpointing Proline Substitution to be Responsible for the Loss of Amyloidogenesis in IAPP Chemical Biology & Drug Design 82
Molecular dynamics simulation reveals that wild type hIAPP 22-28 fibril fluctuates between different β-sheet topology during the simulation. A25P Substitution is primarily accountable for the loss of amyloidogenecity of the hIAPP peptide. A25P, I26V double mutation also exhibit high fibril destabilization ability. S28P mutation has the least ability to disrupt the amyloid fibril.
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