E-mail

E-mail a Wiley Online Library Link

Cindy J. Choy, Melody D. Fulton, Austen L. Davis, Mark Hopkins, Joseph K. Choi, Marc O. Anderson and Clifford E. Berkman Rationally Designed Sulfamides as Glutamate Carboxypeptidase II Inhibitors Chemical Biology & Drug Design 82

Article first published online: 25 SEP 2013 | DOI: 10.1111/cbdd.12174

Thumbnail image of graphical abstract

This current study explores a new class of GCPII inhibitors, glutamyl sulfamides, which possess a neutral tetrahedral zinc-binding motif. A small library containing six sulfamides was prepared and evaluated for inhibitory potency against purified GCPII. While most inhibitors have potencies in the micromolar range, one showed promising sub-micromolar potency, with the optimal inhibitor in this series being aspartyl-glutamyl sulfamide.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH