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Taís Arthur Corrêa, Caio C. S. Alves, Sandra B. R. Castro, Erick E. Oliveira, Lucas S. Franco, Ana P. Ferreira and Mauro V. de Almeida Synthesis of 1,4-Anthracene-9,10-dione Derivatives and Their Regulation of Nitric Oxide, IL-1β and TNF-α in Activated RAW264.7 Cells Chemical Biology & Drug Design 82

Version of Record online: 10 AUG 2013 | DOI: 10.1111/cbdd.12183

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Mono- and disubstituted anthraquinone derivatives were synthesized through the addition of lipophilic amino alcohols. The disubstituted 1,4-anthracene-9,10-dione 10 showed significant inhibition of nitric oxide, TNF-α and IL-1β production, and the monosubstituted derivative 13 displayed a moderate to good inhibitory capacity on IL-1β and nitric oxide production, suggesting better inhibitory capacity of the inflammatory mediators by these compounds.

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