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Radosław Starosta, Aleksandra Bykowska, Agnieszka Kyzioł, Michał Płotek, Magdalena Florek, Jarosław Król and Małgorzata Jeżowska-Bojczuk Copper(I) (Pseudo)Halide Complexes with Neocuproine and Aminomethylphosphines Derived from Morpholine and Thiomorpholine – In Vitro Cytotoxic and Antimicrobial Activity and the Interactions with DNA and Serum Albumins Chemical Biology & Drug Design 82

Version of Record online: 10 AUG 2013 | DOI: 10.1111/cbdd.12187

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A series of copper complexes with tris (aminomethyl) phosphines derived from morpholine or thiomorpholine exhibit a high antimicrobial (against Staphylococcus aureus and Candida albicans) and cytotoxic activity in vitro towards mouse colon carcinoma and human lung adenocarcinoma with IC50 values below 10 μm. To gain insight into the molecular mechanism of biological activity of the complexes, their interactions with plasmid DNA and the human and bovine serum albumins were investigated.

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