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Hardik Bhatt, Paresh Patel and Christophe Pannecouque Discovery of HIV-1 Integrase Inhibitors: Pharmacophore Mapping, Virtual Screening, Molecular Docking, Synthesis, and Biological Evaluation Chemical Biology & Drug Design 83

Article first published online: 4 OCT 2013 | DOI: 10.1111/cbdd.12207

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Computer-aided drug design approaches like pharmacophore mapping, virtual screening, and molecular docking were used to design novel compounds bearing pteridine ring system. Designed compounds were synthesized by conventional and microwave-irradiated methods showing advantage of MWI method. All synthesized compounds were evaluated as HTV-1 integrase inhibitors and further explored to discover novel HIV-I integrase inhibitors.

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