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Theresa Tiefenbrunn, Stefano Forli, Meaghan Happer, Ana Gonzalez, Yingssu Tsai, Michael Soltis, John H. Elder, Arthur J. Olson and Charles D. Stout Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease Chemical Biology & Drug Design 83

Article first published online: 30 OCT 2013 | DOI: 10.1111/cbdd.12227

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X-marks the spot: Weak fragment binding at surface sites is more easily detected in X-ray structures when a halogen atom in the fragment can be localized via an anomalous difference peak. A brominated fragment library elucidates known surface binding sites on HIV-1 protease.

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