Matin Islami, Faramarz Mehrnejad, Farahnoosh Doustdar, Masumeh Alimohammadi, Mahmoud Khadem-Maaref, Mohammad Mir-Derikvand and Majid Taghdir Study of Orientation and Penetration of LAH4 into Lipid Bilayer Membranes: pH and Composition Dependence Chemical Biology & Drug Design 84
In this study, we have performed molecular dynamics simulations to compare LAH4 effects on anionic palmitoyl–oleoyl–phosphatidylglycerol bilayer and zwitterionic palmitoyl–oleoyl–phosphatidylcholine bilayer. The peptide preferentially interacts with anionic membranes. Our data show that electrostatic interactions between His11 and the phosphor atoms of bilayers should have a significant impact on the penetration of LAH4.
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