E-mail a Wiley Online Library Link

Matin Islami, Faramarz Mehrnejad, Farahnoosh Doustdar, Masumeh Alimohammadi, Mahmoud Khadem-Maaref, Mohammad Mir-Derikvand and Majid Taghdir Study of Orientation and Penetration of LAH4 into Lipid Bilayer Membranes: pH and Composition Dependence Chemical Biology & Drug Design 84

Version of Record online: 30 APR 2014 | DOI: 10.1111/cbdd.12311

Thumbnail image of graphical abstract

In this study, we have performed molecular dynamics simulations to compare LAH4 effects on anionic palmitoyl–oleoyl–phosphatidylglycerol bilayer and zwitterionic palmitoyl–oleoyl–phosphatidylcholine bilayer. The peptide preferentially interacts with anionic membranes. Our data show that electrostatic interactions between His11 and the phosphor atoms of bilayers should have a significant impact on the penetration of LAH4.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field